IL5

Across TCGA patient cohorts, IL5 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL5-associated genes across cancer lineages are Notch1, p38-MAPK, and STAT3_pY705. Each is linked with IL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL5-to-partner and partner-to-IL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IL5-low versus IL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL5→partner) and Y-score (partner→IL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.311	+2.820	<.001	.035	3	1
UCEC	p38-MAPK →	-0.262	-2.979	.003	.036	3	1
UCEC	STAT3_pY705 →	-0.644	-3.169	<.001	.018	3	1
UCEC	C-Raf →	+0.266	+3.169	<.001	.020	3	1
UCEC	Cyclin-B1 →	+1.001	+3.169	.001	.020	3	1
UCEC	FASN →	+0.467	+3.169	.030	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by IL5 expression — UCEC

Explore this box plot interactively →