Across TCGA cell cohorts, IL3RA mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible IL3RA-associated genes across cancer lineages are TMEM95, IL3, and PRAMEF10. Each is linked with IL3RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL3RA-to-partner and partner-to-IL3RA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL3RA→partner) and Y-score (partner→IL3RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM95 →	+0.016	+4.022	<.001	.006	3	2
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

IL3RA survival (RNA) · tumor vs normal (RNA) · all IL3RA data types