IL36G

Across TCGA patient cohorts, IL36G mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36G-associated genes across cancer lineages are EGFR_pY1068, GSK3-a-b, and Heregulin. Each is linked with IL36G in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36G-to-partner and partner-to-IL36G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IL36G-low versus IL36G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36G→partner) and Y-score (partner→IL36G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.313	-2.459	.009	.020	3	1
UCEC	GSK3-a-b →	+0.146	+3.169	.025	.019	3	1
UCEC	Heregulin →	-0.142	-2.986	.017	.035	3	1
UCEC	JNK2 →	+0.374	+2.179	<.001	.034	2	2
UCEC	p62 Lck ligand →	+0.498	+2.459	.001	.020	3	1
UCEC	Tuberin →	+0.446	+2.179	<.001	.034	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by IL36G expression — UCEC

Explore this box plot interactively →