IL36B

Across TCGA patient cohorts, IL36B mutation is significantly associated with the RNA expression of many other genes, with 2,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36B-associated genes across cancer lineages are MIR3689B, KIFC1, and SSRP1. Each is linked with IL36B in more than 2 cancer types. Because this analysis shows association rather than direction, both IL36B-to-partner and partner-to-IL36B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3689B grouped by IL36B-low versus IL36B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36B→partner) and Y-score (partner→IL36B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3689B →	+0.306	+5.309	<.001	.003	3	3
SKCM	KIFC1 →	+0.458	+1.502	.001	.003	3	2
UCEC	SSRP1 →	+0.501	+3.639	.005	.001	3	2
UCEC	ALDOA →	+0.512	+2.584	.002	.001	3	2
UCEC	SPC25 →	+0.607	+3.470	.008	.002	3	2
UCEC	EME1 →	+0.585	+2.098	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,534 associations by consensus.

MIR3689B by IL36B expression — LUSC

Explore this box plot interactively →