IL36B

Across TCGA patient cohorts, IL36B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36B-associated genes across cancer lineages are mTOR_pS2448, STAT3_pY705, and Cyclin-B1. Each is linked with IL36B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36B-to-partner and partner-to-IL36B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by IL36B-low versus IL36B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36B→partner) and Y-score (partner→IL36B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.162	-1.807	.008	.027	3	2
UCEC	STAT3_pY705 →	-0.505	-2.321	<.001	.006	3	2
UCEC	Cyclin-B1 →	+0.817	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.017	.009	3	1
UCEC	eEF2 →	+0.290	+3.169	.049	.018	3	1
UCEC	EGFR_pY1068 →	-0.306	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

mTOR_pS2448 by IL36B expression — UCEC

Explore this box plot interactively →