IL36B

Across TCGA cell cohorts, IL36B mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IL36B-associated genes across cancer lineages are C4orf50 and TMEM235. Each is linked with IL36B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36B-to-partner and partner-to-IL36B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by IL36B-low versus IL36B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36B→partner) and Y-score (partner→IL36B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C4orf50 →	+0.025	+5.099	<.001	<.001	3	1
SKIN	TMEM235 →	+0.005	+4.217	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

C4orf50 by IL36B expression — SKIN

Explore this box plot interactively →