IL36A

Across TCGA pan-cancer cohorts, IL36A mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IL36A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL36A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IL36A is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC are the cancer types where IL36A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL36A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.635	<.001	11	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

IL36A–HNSC

Open the HNSC breakdown →