IL32

Across TCGA patient cohorts, IL32 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL32-associated genes across cancer lineages are CDK1, Heregulin, and Ku80. Each is linked with IL32 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL32-to-partner and partner-to-IL32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by IL32-low versus IL32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL32→partner) and Y-score (partner→IL32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.230	+3.000	.008	.037	3	2
UCEC	Heregulin →	-0.247	-3.000	<.001	.036	3	1
UCEC	Ku80 →	+0.342	+3.013	.012	.019	3	1
UCEC	MEK1 →	+0.568	+3.000	.007	.036	3	1
UCEC	SCD →	-0.203	-2.990	.001	.036	3	1
UCEC	SF2 →	-0.189	-2.986	.002	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

CDK1 by IL32 expression — UCEC

Explore this box plot interactively →