Across TCGA pan-cancer cohorts, IL31 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IL31’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where IL31 RNA is repressed in tumor relative to normal tissue. In most cancer types IL31 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where IL31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.039	.017	3	view →
HNSC	All	All	+0.094	.039	2	view →
LIHC	All	All	+0.133	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IL31 RNA expression & survival · all IL31 data types