IL2RG

Across TCGA patient cohorts, IL2RG protein abundance is significantly associated with the RNA expression of many other genes, with 6,978 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL2RG-associated genes across cancer lineages are CCNB1IP1, ABHD4, and POFUT1. Each is linked with IL2RG in more than 2 cancer types. Because this analysis shows association rather than direction, both IL2RG-to-partner and partner-to-IL2RG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL2RG versus CCNB1IP1 in LSCC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RG→partner) and Y-score (partner→IL2RG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCNB1IP1 →	-0.849	-1.045	<.001	<.001	3	3
LSCC	ABHD4 →	-1.060	-0.737	<.001	.001	3	2
LSCC	POFUT1 →	-0.647	-0.741	.001	.002	3	2
LSCC	POLE4 →	-0.550	-0.744	<.001	.001	3	2
LSCC	UBAC1 →	-0.681	-0.947	<.001	<.001	3	2
PDAC	CIZ1 →	-0.665	-1.238	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,978 associations by consensus.

IL2RG vs CCNB1IP1 — LSCC

Explore this scatter interactively →