IL2RG

Across TCGA patient cohorts, IL2RG mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL2RG-associated genes across cancer lineages are 14-3-3_beta, eEF2, and Fibronectin. Each is linked with IL2RG in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RG-to-partner and partner-to-IL2RG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IL2RG-low versus IL2RG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RG→partner) and Y-score (partner→IL2RG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-3.432	.020	.005	3	1
UCEC	eEF2 →	+0.274	+3.169	.033	.018	3	1
UCEC	Fibronectin →	-0.286	-3.308	.015	.009	3	1
UCEC	GATA6 →	-0.124	-1.758	.033	.014	3	1
UCEC	JNK_pT183_Y185 →	-0.147	-2.115	.015	.017	3	1
UCEC	JNK2 →	+0.180	+1.901	.012	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by IL2RG expression — UCEC

Explore this box plot interactively →