IL2RG

Across TCGA cell cohorts, IL2RG RNA expression is significantly associated with the go_rna of many other GO terms, with 3,406 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL2RG-associated GO terms across cancer lineages are Basement membrane disassembly, Regulation of type III interferon production, and Interleukin-2-mediated signaling pathway. Each is linked with IL2RG in more than 8 cancer types. Because this analysis shows association rather than direction, both IL2RG-to-partner and partner-to-IL2RG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Basement membrane disassembly grouped by IL2RG-low versus IL2RG-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RG→partner) and Y-score (partner→IL2RG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Basement membrane disassembly →	+1.509	+2.566	<.001	<.001	3	9
BREAST	Regulation of type III interferon production →	+1.165	+0.823	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Interleukin-2-mediated signaling pathway →	-0.227	-0.942	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Cellular response to interleukin-2 →	-0.227	-0.942	<.001	<.001	3	7
LARGE_INTESTINE	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.190	+2.872	<.001	<.001	3	7
LARGE_INTESTINE	Antigen processing and presentation of peptide antigen via MHC class I →	+0.124	+2.285	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,406 associations by consensus.

Basement membrane disassembly by IL2RG expression — PANCREAS

Explore this box plot interactively →