IL25

Across TCGA patient cohorts, IL25 mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL25-associated genes across cancer lineages are MTND2P38, GPR75-ASB3, and OR2G3. Each is linked with IL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL25-to-partner and partner-to-IL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P38 grouped by IL25-low versus IL25-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL25→partner) and Y-score (partner→IL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND2P38 →	+0.029	+3.625	<.001	.004	3	2
UCEC	GPR75-ASB3 →	+0.075	+2.756	.002	.004	3	2
COAD	OR2G3 →	+0.072	+5.392	<.001	.002	3	2
UCEC	AQP7P1 →	+0.451	+2.862	<.001	.003	3	2
COAD	TAB2-AS1 →	+0.123	+4.602	<.001	.008	3	2
SKCM	RNU7-141P →	+0.401	+3.253	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

MTND2P38 by IL25 expression — SKCM

Explore this box plot interactively →