IL25

Across TCGA patient cohorts, IL25 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL25-associated genes across cancer lineages are INPP4B, MEK1, and PEA-15. Each is linked with IL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL25-to-partner and partner-to-IL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by IL25-low versus IL25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL25→partner) and Y-score (partner→IL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.375	-3.169	.016	.019	3	1
UCEC	MEK1 →	+0.524	+2.459	.002	.020	3	1
UCEC	PEA-15 →	+0.205	+3.169	.024	.019	3	1
UCEC	Annexin-1 →	+0.557	+2.827	.028	.035	3	1
UCEC	Rictor_pT1135 →	-0.159	-3.584	.001	.002	3	1
UCEC	Caspase-7-cleavedD198 →	+1.027	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

INPP4B by IL25 expression — UCEC

Explore this box plot interactively →