IL22RA2

Across TCGA patient cohorts, IL22RA2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL22RA2-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with IL22RA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL22RA2-to-partner and partner-to-IL22RA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IL22RA2-low versus IL22RA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22RA2→partner) and Y-score (partner→IL22RA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.326	-2.584	.005	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.220	-2.571	.004	.011	3	1
UCEC	JNK2 →	+0.202	+3.009	.029	.019	3	1
UCEC	Ku80 →	+0.347	+3.335	.001	.005	3	1
UCEC	MEK1 →	+0.344	+2.584	.043	.011	3	1
UCEC	PKC-delta_pS664 →	-0.140	-3.160	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by IL22RA2 expression — UCEC

Explore this box plot interactively →