IL22RA1

Across TCGA patient cohorts, IL22RA1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL22RA1-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with IL22RA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL22RA1-to-partner and partner-to-IL22RA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IL22RA1-low versus IL22RA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22RA1→partner) and Y-score (partner→IL22RA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.199	+2.710	<.001	.003	3	4
UCEC	Caspase-7-cleavedD198 →	+0.611	+2.019	.008	.017	3	2
UCEC	EGFR_pY1068 →	-0.281	-3.807	.004	<.001	3	1
UCEC	eIF4G →	+0.257	+1.584	.034	.036	3	1
UCEC	A-Raf_pS299 →	-0.107	-2.584	.022	.010	3	1
UCEC	ERK2 →	+0.215	+3.459	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by IL22RA1 expression — UCEC

Explore this box plot interactively →