IL22RA1

Across TCGA cell cohorts, IL22RA1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL22RA1-associated genes across cancer lineages are GOLGA6L6, MAGEB4, and STRA8. Each is linked with IL22RA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL22RA1-to-partner and partner-to-IL22RA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L6 grouped by IL22RA1-low versus IL22RA1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22RA1→partner) and Y-score (partner→IL22RA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GOLGA6L6 →	+0.006	+5.228	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ACCSL →	+0.023	+4.273	<.001	.006	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GOLGA6L6 by IL22RA1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →