IL21R-AS1

Across TCGA pan-cancer cohorts, IL21R-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IL21R-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IL21R-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IL21R-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, KIRC, and SKCM are the cancer types where IL21R-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.411	0.207	<.001	138	view →
KIRC	DFS	Median	All	0.531	0.704	<.001	122	view →
SKCM	OS	Median	All	0.414	0.276	<.001	120	view →
UVM	DFS	Median	II,III,IV	0.587	0.883	<.001	99	view →
ACC	DFS	Quartile	All	0.228	0.703	<.001	70	view →
LUAD	DFS	Median	II,III,IV	0.728	0.439	<.001	44	view →
CESC	OS	Quartile	All	0.792	0.504	<.001	44	view →
KIRP	DFS	Quartile	All	0.538	0.795	<.001	44	view →
THYM	DFS	Median	All	0.645	0.861	<.001	36	view →
PAAD	OS	Tertile	All	0.637	0.354	.009	35	view →
PRAD	DFS	Median	All	0.818	0.942	<.001	22	view →
MESO	OS	Tertile	IV	0.368	0.805	.013	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IL21R-AS1–HNSC (DFS)

Open the HNSC breakdown →