IL21

Across TCGA patient cohorts, IL21 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL21-associated genes across cancer lineages are OR8B10P, RPL34P3, and NIPA2P5. Each is linked with IL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL21-to-partner and partner-to-IL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B10P grouped by IL21-low versus IL21-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL21→partner) and Y-score (partner→IL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR8B10P →	+0.068	+5.303	<.001	.006	3	2
HNSC	RPL34P3 →	+0.280	+5.505	<.001	.004	3	2
LUSC	NIPA2P5 →	+0.179	+5.625	<.001	.004	3	2
UCEC	DDAH1 →	+0.951	+3.202	.003	.009	3	1
UCEC	WHAMM →	+0.665	+3.386	<.001	.004	3	1
UCEC	PYHIN1 →	+0.642	+3.332	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

OR8B10P by IL21 expression — HNSC

Explore this box plot interactively →