IL21

Across TCGA patient cohorts, IL21 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL21-associated genes across cancer lineages are STAT3_pY705, Chk2, and YB-1. Each is linked with IL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL21-to-partner and partner-to-IL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by IL21-low versus IL21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL21→partner) and Y-score (partner→IL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.526	-2.999	<.001	.035	3	1
UCEC	Chk2 →	-0.295	-3.169	.021	.020	3	1
SKCM	YB-1 →	+0.250	+3.012	.019	.018	2	1
UCEC	Annexin-1 →	+0.789	+3.169	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

STAT3_pY705 by IL21 expression — UCEC

Explore this box plot interactively →