Across TCGA pan-cancer cohorts, IL21-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IL21-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IL21-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL21-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRP, HNSC, and SKCM are the cancer types where IL21-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.546	0.812	<.001	187	view →
HNSC	DFS	Median	All	0.756	0.634	<.001	134	view →
SKCM	OS	Tertile	All	0.450	0.271	<.001	108	view →
LUAD	DFS	Quartile	III,IV	0.887	0.529	<.001	83	view →
CESC	DFS	Median	All	0.877	0.763	.003	62	view →
LGG	OS	Median	All	0.742	0.866	<.001	51	view →
BLCA	OS	Median	All	0.772	0.655	.002	44	view →
READ	DFS	Median	II,III,IV	0.541	0.773	.003	41	view →
KIRC	DFS	Tertile	All	0.711	0.879	.001	38	view →
UCEC	OS	Quartile	All	0.782	0.600	.008	34	view →
KICH	DFS	Tertile	III,IV	0.285	1.000	.006	25	view →
LUSC	DFS	Quartile	II,III,IV	0.615	0.788	.005	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: IL21-AS1 tumor-vs-normal RNA expression · all IL21-AS1 data types