Across TCGA pan-cancer cohorts, IL20RA mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IL20RA’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where IL20RA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IL20RA is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.
PDAC are the cancer types where IL20RA tumor–normal differential expression is most reproducible.