IL20

Across TCGA pan-cancer cohorts, IL20 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IL20’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL20 RNA is repressed in tumor relative to normal tissue. In most cancer types IL20 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, COAD, and BRCA are the cancer types where IL20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.168	<.001	12	view →
COAD	All	II,III,IV	+0.097	.001	8	view →
BRCA	All	III,IV	+2.135	<.001	6	view →
UCEC	All	All	−0.371	.010	6	view →
KIRP	All	All	−0.110	.001	6	view →
LUAD	All	All	−0.143	.020	4	view →
PRAD	All	All	−0.419	<.001	2	view →
LUSC	Male	All	+0.301	.039	1	view →
KICH	All	All	+0.289	.049	1	view →
THCA	Male	III,IV	−0.044	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IL20–KIRC

Open the KIRC breakdown →