IL2

Across TCGA cell cohorts, IL2 RNA expression is significantly associated with the mutation status of many other genes, with 148 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL2-associated genes across cancer lineages are FBXL18, ABCB4, and OSBPL6. Each is linked with IL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2-to-partner and partner-to-IL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXL18 grouped by IL2-low versus IL2-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2→partner) and Y-score (partner→IL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXL18 →	+2.276	+0.299	.002	.008	3	2
BLOOD_Leukemia	ABCB4 →	+4.013	+0.636	<.001	<.001	3	2
BLOOD_Leukemia	OSBPL6 →	+3.691	+0.662	.002	<.001	3	2
LUNG_NSCLC_LUAD	BACH1 →	+3.734	+0.031	.006	.001	3	2
BLOOD_Leukemia	TOP3A →	+2.691	+0.400	.003	.002	3	2
LARGE_INTESTINE	CAPS2 →	+4.022	+0.040	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

FBXL18 by IL2 expression — BLOOD_Leukemia

Explore this box plot interactively →