IL1RL1

Across TCGA patient cohorts, IL1RL1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1RL1-associated genes across cancer lineages are PDCD4, Src_pY416, and STAT3_pY705. Each is linked with IL1RL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL1RL1-to-partner and partner-to-IL1RL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by IL1RL1-low versus IL1RL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RL1→partner) and Y-score (partner→IL1RL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.711	-3.169	<.001	.018	3	2
UCEC	Src_pY416 →	-0.208	-2.102	.048	.019	3	2
UCEC	STAT3_pY705 →	-0.466	-3.459	<.001	.005	3	2
LUAD	p38-MAPK_pT180_Y182 →	-0.392	-3.169	.034	.019	3	1
UCEC	Cyclin-B1 →	+0.696	+2.807	.004	.003	1	3
UCEC	EGFR_pY1068 →	-0.334	-3.906	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by IL1RL1 expression — UCEC

Explore this box plot interactively →