Across TCGA pan-cancer cohorts, IL1RAP Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IL1RAP data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IL1RAP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IL1RAP expression acts as an unfavorable survival marker.

HNSC, LUSC, and UCEC are the cancer types where IL1RAP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.147	0.648	.015	24	view →
LUSC	OS	Median	III,IV	0.147	0.664	.028	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IL1RAP tumor-vs-normal RNA expression · all IL1RAP data types