Across TCGA pan-cancer cohorts, IL1RAP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IL1RAP data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IL1RAP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IL1RAP expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where IL1RAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.583	0.949	.002	69	view →
LUAD	DFS	Tertile	III,IV	0.302	0.901	.003	15	view →
LSCC	OS	Quartile	II,III,IV	0.431	0.844	.020	7	view →
CCRCC	OS	Median	III,IV	0.712	0.942	.014	3	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.932	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IL1RAP tumor-vs-normal RNA expression · all IL1RAP data types