Across TCGA patient cohorts, IL1RAP mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1RAP-associated genes across cancer lineages are p38-MAPK_pT180_Y182, JNK_pT183_Y185, and STAT3_pY705. Each is linked with IL1RAP in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1RAP-to-partner and partner-to-IL1RAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RAP→partner) and Y-score (partner→IL1RAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	p38-MAPK_pT180_Y182 →	-0.425	-2.993	.020	.038	3	2
UCEC	JNK_pT183_Y185 →	-0.133	-1.700	.036	.042	3	2
UCEC	STAT3_pY705 →	-0.375	-1.765	<.001	.014	3	2
UCEC	ATM →	-0.516	-2.169	.002	.003	3	2
BRCA	IRF-1 →	+0.295	+3.006	.001	.020	3	1
BRCA	p38-MAPK →	-0.321	-2.993	.001	.038	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

IL1RAP survival (RNA) · tumor vs normal (RNA) · all IL1RAP data types