IL1R2

Across TCGA cell cohorts, IL1R2 mutation is significantly associated with the RNA expression of many other genes, with 1,107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL1R2-associated genes across cancer lineages are ANKRD33, OR6B3, and OR4A47. Each is linked with IL1R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1R2-to-partner and partner-to-IL1R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD33 grouped by IL1R2-low versus IL1R2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1R2→partner) and Y-score (partner→IL1R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANKRD33 →	+0.003	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	OR6B3 →	+0.030	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR4A47 →	+0.013	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	MUC22 →	+0.034	+3.714	.006	.006	3	1
SKIN	HPGDS →	+0.051	+3.823	.004	.006	3	1
LUNG_NSCLC_LUAD	SPRR2G →	+0.115	+3.481	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,107 associations by consensus.

ANKRD33 by IL1R2 expression — BLOOD_Lymphoma

Explore this box plot interactively →