IL1R2

Across TCGA cell cohorts, IL1R2 mutation is significantly associated with the mutation status of many other genes, with 5,247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL1R2-associated genes across cancer lineages are UNC80, FAM135B, and PLXNA4. Each is linked with IL1R2 in more than 4 cancer types. Because this analysis shows association rather than direction, both IL1R2-to-partner and partner-to-IL1R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC80 grouped by IL1R2-low versus IL1R2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1R2→partner) and Y-score (partner→IL1R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UNC80 →	+4.502	+5.066	.007	.007	1	5
SKIN	FAM135B →	+2.321	+3.019	.003	.003	1	5
LARGE_INTESTINE	PLXNA4 →	+2.456	+3.884	<.001	<.001	1	5
LUNG_NSCLC_LUAD	MYO5C →	+3.396	+4.078	<.001	<.001	1	4
LUNG_NSCLC_LUAD	PCDH10 →	+2.581	+4.430	<.001	<.001	1	4
LUNG_NSCLC_LUAD	NPAS3 →	+3.718	+3.718	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,247 associations by consensus.

UNC80 by IL1R2 expression — SOFT_TISSUE

Explore this box plot interactively →