IL1R1

Across TCGA pan-cancer cohorts, IL1R1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IL1R1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher IL1R1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL1R1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, SKCM, and LUSC are the cancer types where IL1R1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.032	0.762	<.001	30	view →
SKCM	DFS	Median	II,III,IV	0.220	0.716	<.001	14	view →
LUSC	DFS	Median	All	0.135	0.397	.007	10	view →
SARC	DFS	Median	All	0.094	0.591	.004	6	view →
COAD	OS	Median	All	0.500	0.871	.013	6	view →
GBM	OS	Median	All	0.089	0.415	.037	3	view →
UCEC	DFS	Median	All	0.944	0.625	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IL1R1–UVM (DFS)

Open the UVM breakdown →