IL1B

Across TCGA patient cohorts, IL1B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1B-associated genes across cancer lineages are EGFR_pY1068, GSK-3_pS9, and IGFBP2. Each is linked with IL1B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1B-to-partner and partner-to-IL1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IL1B-low versus IL1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1B→partner) and Y-score (partner→IL1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.000	.018	.032	3	1
UCEC	GSK-3_pS9 →	-0.436	-2.999	.016	.035	3	1
UCEC	IGFBP2 →	-0.642	-2.000	.028	.032	3	1
UCEC	MEK1 →	+0.475	+2.700	.003	.006	3	1
UCEC	MSH2 →	-0.211	-2.990	.042	.036	3	1
UCEC	mTOR_pS2448 →	-0.143	-3.156	.033	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by IL1B expression — UCEC

Explore this box plot interactively →