IL1B

Across TCGA cell cohorts, IL1B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,564 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IL1B-associated GO terms across cancer lineages are Positive regulation of complement activation, Regulation of fibroblast proliferation, and Negative regulation of interleukin-1 beta production. Each is linked with IL1B in more than 11 cancer types. Because this analysis shows association rather than direction, both IL1B-to-partner and partner-to-IL1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of complement activation grouped by IL1B-low versus IL1B-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1B→partner) and Y-score (partner→IL1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of complement activation →	+1.902	+4.286	<.001	.001	3	12
PANCREAS	Regulation of fibroblast proliferation →	+0.110	+3.002	.001	<.001	3	12
URINARY_TRACT	Negative regulation of interleukin-1 beta production →	+0.131	+3.154	<.001	.001	3	11
BREAST	Regulation of interleukin-1 beta production →	+0.099	+1.230	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of interleukin-1 production →	+0.136	+4.038	<.001	<.001	3	11
BREAST	Fibrinolysis →	+1.416	+2.399	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,564 associations by consensus.

Positive regulation of complement activation by IL1B expression — URINARY_TRACT

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