IL1B

Across TCGA cell cohorts, IL1B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL1B-associated genes across cancer lineages are FAM71B, C20orf85, and IL22. Each is linked with IL1B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1B-to-partner and partner-to-IL1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by IL1B-low versus IL1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1B→partner) and Y-score (partner→IL1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71B →	+0.003	+4.022	<.001	.006	3	2
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR2A5 →	+0.021	+4.922	<.001	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FAM71B by IL1B expression — LARGE_INTESTINE

Explore this box plot interactively →