IL1A

Across TCGA cell cohorts, IL1A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,909 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IL1A-associated GO terms across cancer lineages are Negative regulation of interleukin-1 alpha production, Wound healing, and Positive regulation of complement activation. Each is linked with IL1A in more than 9 cancer types. Because this analysis shows association rather than direction, both IL1A-to-partner and partner-to-IL1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of interleukin-1 alpha production grouped by IL1A-low versus IL1A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1A→partner) and Y-score (partner→IL1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of interleukin-1 alpha production →	+1.068	+2.117	.001	.006	3	10
STOMACH	Wound healing →	+0.088	+2.059	.001	.006	3	10
SKIN	Positive regulation of complement activation →	+1.944	+3.492	<.001	<.001	3	10
OESOPHAGUS	Regulation of positive chemotaxis →	+0.205	+2.190	.001	.002	3	10
OESOPHAGUS	Positive regulation of positive chemotaxis →	+0.205	+2.190	.001	.002	3	10
PANCREAS	Regulation of cell adhesion molecule production →	+1.114	+2.627	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,909 associations by consensus.

Negative regulation of interleukin-1 alpha production by IL1A expression — LUNG_NSCLC_LUSC

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