IL19

Across TCGA pan-cancer cohorts, IL19 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IL19’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL19 RNA is repressed in tumor relative to normal tissue. In most cancer types IL19 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where IL19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.234	<.001	12	view →
KIRP	All	All	−0.223	<.001	9	view →
HNSC	All	II,III,IV	−1.009	<.001	7	view →
UCEC	All	All	+1.158	<.001	6	view →
BRCA	All	II,III,IV	+0.428	<.001	6	view →
KICH	All	All	−0.254	<.001	6	view →
THCA	Male	All	−0.108	.001	6	view →
LUAD	Female	All	+0.122	.004	3	view →
LUSC	Male	All	+0.210	<.001	2	view →
PRAD	All	All	−0.087	.003	2	view →
STAD	All	IV	−1.996	.014	1	view →
BLCA	Male	III,IV	+0.240	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IL19–KIRC

Open the KIRC breakdown →