IL18RAP

Across TCGA pan-cancer cohorts, IL18RAP mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IL18RAP’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where IL18RAP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IL18RAP is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where IL18RAP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL18RAP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.817	<.001	8	view →
LUAD	Female	II,III,IV	+1.015	.008	2	view →
CCRCC	All	All	−0.992	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IL18RAP–LSCC

Open the LSCC breakdown →