IL18RAP

Across TCGA cell cohorts, IL18RAP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,324 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IL18RAP-associated GO terms across cancer lineages are Negative regulation of cytokine production, Negative regulation of cell activation, and Negative regulation of cell-cell adhesion. Each is linked with IL18RAP in more than 7 cancer types. Because this analysis shows association rather than direction, both IL18RAP-to-partner and partner-to-IL18RAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine production grouped by IL18RAP-low versus IL18RAP-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18RAP→partner) and Y-score (partner→IL18RAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of cytokine production →	+0.062	+0.084	<.001	.008	3	8
BLOOD_Lymphoma	Negative regulation of cell activation →	+0.059	+1.118	<.001	<.001	3	7
BLOOD_Leukemia	Negative regulation of cell-cell adhesion →	+0.054	+0.902	<.001	<.001	3	6
BLOOD_Leukemia	Fibrinolysis →	+0.766	+0.998	.001	<.001	3	6
BLOOD_Lymphoma	Positive regulation of canonical NF-kappaB signal transduction →	+0.052	+0.848	<.001	<.001	3	6
BLOOD_Leukemia	Regulation of alpha-beta T cell activation →	+0.076	+1.015	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,324 associations by consensus.

Negative regulation of cytokine production by IL18RAP expression — SOFT_TISSUE

Explore this box plot interactively →