IL18RAP

Across TCGA cell cohorts, IL18RAP mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL18RAP-associated genes across cancer lineages are RNASE3, FAM71B, and KRTAP9-3. Each is linked with IL18RAP in more than 1 cancer types. Because this analysis shows association rather than direction, both IL18RAP-to-partner and partner-to-IL18RAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE3 grouped by IL18RAP-low versus IL18RAP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18RAP→partner) and Y-score (partner→IL18RAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNASE3 →	+0.054	+3.817	<.001	.004	3	1
LUNG_SCLC	FAM71B →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP9-3 →	+0.033	+4.058	<.001	.007	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ACTRT2 →	+0.064	+4.922	.001	.009	3	1
BLOOD_Leukemia	DEFB4B →	+0.313	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNASE3 by IL18RAP expression — LUNG_SCLC

Explore this box plot interactively →