IL18RAP

Across TCGA cell cohorts, IL18RAP mutation is significantly associated with the mutation status of many other genes, with 3,546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL18RAP-associated genes across cancer lineages are VEPH1, ATP2B3, and SLC4A3. Each is linked with IL18RAP in more than 3 cancer types. Because this analysis shows association rather than direction, both IL18RAP-to-partner and partner-to-IL18RAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEPH1 grouped by IL18RAP-low versus IL18RAP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18RAP→partner) and Y-score (partner→IL18RAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VEPH1 →	+4.459	+5.277	.005	.005	1	4
BLOOD_Leukemia	ATP2B3 →	+4.157	+5.430	<.001	<.001	1	4
BLOOD_Leukemia	SLC4A3 →	+2.894	+4.432	.005	.005	1	4
LARGE_INTESTINE	UGGT2 →	+3.000	+3.369	<.001	<.001	1	4
LARGE_INTESTINE	PRRC2B →	+2.106	+4.185	<.001	<.001	1	4
LARGE_INTESTINE	INSRR →	+2.125	+3.278	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,546 associations by consensus.

VEPH1 by IL18RAP expression — CNS

Explore this box plot interactively →