IL18R1

Across TCGA patient cohorts, IL18R1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL18R1-associated genes across cancer lineages are eEF2, ACC1, and FoxM1. Each is linked with IL18R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL18R1-to-partner and partner-to-IL18R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by IL18R1-low versus IL18R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18R1→partner) and Y-score (partner→IL18R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.390	+1.700	.010	.044	3	3
LUAD	ACC1 →	-0.565	-3.000	.008	.036	3	2
SKCM	FoxM1 →	+0.172	+2.321	.036	.032	3	2
SKCM	Rictor_pT1135 →	-0.154	-3.321	.012	.009	3	2
UCEC	Caspase-8 →	-0.255	-2.558	.016	.010	3	2
UCEC	Cyclin-B1 →	+0.697	+3.169	.003	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by IL18R1 expression — UCEC

Explore this box plot interactively →