IL18R1

Across TCGA cell cohorts, IL18R1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,998 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IL18R1-associated GO terms across cancer lineages are Interleukin-18-mediated signaling pathway, Cellular response to interleukin-18, and Biological process involved in symbiotic interaction. Each is linked with IL18R1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IL18R1-to-partner and partner-to-IL18R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-18-mediated signaling pathway grouped by IL18R1-low versus IL18R1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18R1→partner) and Y-score (partner→IL18R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Interleukin-18-mediated signaling pathway →	-0.254	-0.914	<.001	<.001	3	10
BONE	Cellular response to interleukin-18 →	-0.254	-0.914	<.001	<.001	3	10
BONE	Biological process involved in symbiotic interaction →	+0.108	+0.926	<.001	<.001	3	9
SOFT_TISSUE	Negative regulation of immune response →	+0.086	+0.915	<.001	.006	3	9
BREAST	Cellular response to chemical stress →	+0.042	+0.473	.002	.006	3	9
BONE	Positive regulation of canonical NF-kappaB signal transduction →	+0.078	+0.939	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,998 associations by consensus.

Interleukin-18-mediated signaling pathway by IL18R1 expression — BONE

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