IL18R1

Across TCGA cell cohorts, IL18R1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL18R1-associated genes across cancer lineages are MAGEB4, ARGFX, and OR2W1. Each is linked with IL18R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL18R1-to-partner and partner-to-IL18R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by IL18R1-low versus IL18R1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18R1→partner) and Y-score (partner→IL18R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAGEB4 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.014	+4.662	.002	.005	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.021	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.050	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.039	+5.472	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MAGEB4 by IL18R1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →