IL18BP

Across TCGA cell cohorts, IL18BP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,782 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IL18BP-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Regulation of mRNA splicing, via spliceosome, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with IL18BP in more than 16 cancer types. Because this analysis shows association rather than direction, both IL18BP-to-partner and partner-to-IL18BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by IL18BP-low versus IL18BP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18BP→partner) and Y-score (partner→IL18BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of DNA-templated transcription initiation →	+0.121	+1.045	.001	.007	3	17
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.138	+1.550	<.001	<.001	3	17
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.121	+1.045	.001	.007	3	17
PANCREAS	Negative regulation of autophagy →	+0.072	+0.816	<.001	<.001	3	16
SOFT_TISSUE	Late viral transcription →	+0.154	+1.284	<.001	<.001	3	16
BONE	RNA localization →	+0.104	+1.006	.001	.007	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,782 associations by consensus.

Negative regulation of DNA-templated transcription initiation by IL18BP expression — BONE

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