IL17RD

Across TCGA patient cohorts, IL17RD mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17RD-associated genes across cancer lineages are Src_pY416, 14-3-3_beta, and ERK2. Each is linked with IL17RD in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RD-to-partner and partner-to-IL17RD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by IL17RD-low versus IL17RD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RD→partner) and Y-score (partner→IL17RD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src_pY416 →	-0.377	-3.000	.007	.034	3	2
UCEC	14-3-3_beta →	-0.081	-2.673	.012	.005	3	2
UCEC	ERK2 →	+0.165	+1.765	.008	.013	3	2
UCEC	MEK1 →	+0.368	+1.925	.001	.004	3	2
UCEC	MSH2 →	-0.321	-3.061	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.507	+2.189	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Src_pY416 by IL17RD expression — SKCM

Explore this box plot interactively →