IL17RD

Across TCGA cell cohorts, IL17RD mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL17RD-associated genes across cancer lineages are SULT2A1, CFHR5, and MS4A15. Each is linked with IL17RD in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RD-to-partner and partner-to-IL17RD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT2A1 grouped by IL17RD-low versus IL17RD-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RD→partner) and Y-score (partner→IL17RD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SULT2A1 →	+0.121	+4.054	<.001	.004	3	1
SKIN	CFHR5 →	+0.008	+4.437	<.001	.004	3	1
SKIN	MS4A15 →	+0.047	+3.678	.003	.009	3	1
SKIN	CETN1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OR1D5 →	+0.014	+4.437	<.001	.004	3	1
LARGE_INTESTINE	NISCH →	+0.734	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

SULT2A1 by IL17RD expression — SKIN

Explore this box plot interactively →