IL17RC

Across TCGA patient cohorts, IL17RC mutation is significantly associated with the RNA expression of many other genes, with 3,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17RC-associated genes across cancer lineages are RN7SL83P, SRRD, and RHBDD3. Each is linked with IL17RC in more than 2 cancer types. Because this analysis shows association rather than direction, both IL17RC-to-partner and partner-to-IL17RC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL83P grouped by IL17RC-low versus IL17RC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RC→partner) and Y-score (partner→IL17RC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL83P →	+0.499	+4.392	<.001	.006	3	3
UCEC	SRRD →	+0.420	+2.947	.001	<.001	3	2
UCEC	RHBDD3 →	+0.396	+2.906	.003	.001	3	2
SKCM	CDKN3 →	+0.727	+3.478	<.001	.002	3	2
UCEC	DHRS2 →	+0.869	+2.158	<.001	<.001	3	2
UCEC	SRP54 →	+0.413	+1.850	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

RN7SL83P by IL17RC expression — COAD

Explore this box plot interactively →