IL17RC

Across TCGA cell cohorts, IL17RC mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL17RC-associated genes across cancer lineages are ARMH2, C7orf33, and GUCA2A. Each is linked with IL17RC in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RC-to-partner and partner-to-IL17RC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMH2 grouped by IL17RC-low versus IL17RC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RC→partner) and Y-score (partner→IL17RC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARMH2 →	+0.127	+3.023	.003	.002	3	2
LUNG_NSCLC_LUSC	C7orf33 →	+0.435	+4.584	<.001	.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
BREAST	KRT25 →	+0.063	+4.421	<.001	.004	3	1
LARGE_INTESTINE	SOX17 →	+0.033	+4.054	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ARMH2 by IL17RC expression — LARGE_INTESTINE

Explore this box plot interactively →