IL17RA

Across TCGA cell cohorts, IL17RA mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL17RA-associated genes across cancer lineages are NPY, CST9L, and RLN3. Each is linked with IL17RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RA-to-partner and partner-to-IL17RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY grouped by IL17RA-low versus IL17RA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RA→partner) and Y-score (partner→IL17RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPY →	+1.368	+3.517	.005	.005	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
OESOPHAGUS	GH2 →	+0.035	+4.857	<.001	<.001	3	1
OESOPHAGUS	CCDC42 →	+0.057	+4.017	<.001	.007	3	1
OESOPHAGUS	CACNG5 →	+0.101	+4.017	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

NPY by IL17RA expression — SKIN

Explore this box plot interactively →