IL17D

Across TCGA patient cohorts, IL17D mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IL17D-associated genes across cancer lineages are RNU6-751P, PRR23D3P, and OR1D2. Each is linked with IL17D in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17D-to-partner and partner-to-IL17D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-751P grouped by IL17D-low versus IL17D-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17D→partner) and Y-score (partner→IL17D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-751P →	+0.427	+7.930	<.001	.008	3	1
LUAD	PRR23D3P →	+0.184	+7.930	<.001	.008	3	1
SKCM	OR1D2 →	+0.088	+5.436	<.001	.005	3	1
SKCM	RNU1-93P →	+0.219	+5.436	<.001	.005	3	1
SKCM	RNU6-13P →	+0.413	+5.594	<.001	.004	3	1
SKCM	RNU2-18P →	+0.289	+5.362	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

RNU6-751P by IL17D expression — LUAD

Explore this box plot interactively →